Novel pharmacological targets for the treatment of Parkinson's disease
Identifieur interne : 000243 ( France/Analysis ); précédent : 000242; suivant : 000244Novel pharmacological targets for the treatment of Parkinson's disease
Auteurs : Anthony H. V. Schapira [Royaume-Uni] ; Erwan Bezard [France] ; Jonathan Brotchie [Canada] ; Frdric Calon [Canada] ; Graham L. Collingridge [Royaume-Uni] ; Borris Ferger [Allemagne] ; Bastian Hengerer [Allemagne] ; Etienne Hirsch [France] ; Peter Jenner [Royaume-Uni] ; Nicolas Le Novre [Royaume-Uni] ; Jos A. Obeso [Espagne] ; Michael A. Schwarzschild [États-Unis] ; Umberto Spampinato [France] ; Giora Davidai [États-Unis]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2006-10.
Abstract
Dopamine deficiency, caused by the degeneration of nigrostriatal dopaminergic neurons, is the cause of the major clinical motor symptoms of Parkinson's disease. These symptoms can be treated successfully with a range of drugs that include levodopa, inhibitors of the enzymatic breakdown of levodopa and dopamine agonists delivered by oral, subcutaneous, transcutaneous, intravenous or intra-duodenal routes. However, Parkinson's disease involves degeneration of non-dopaminergic neurons and the treatment of the resulting predominantly non-motor features remains a challenge. This review describes the important recent advances that underlie the development of novel dopaminergic and non-dopaminergic drugs for Parkinson's disease, and also for the motor complications that arise from the use of existing therapies.
Url:
DOI: 10.1038/nrd2087
Affiliations:
- Allemagne, Canada, Espagne, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Île-de-France
- Londres, Paris
- University College de Londres
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ISTEX:D55D8BFC5FD073A4CB0D97FCCF59DCCC515F0D7ALe document en format XML
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Schapira</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF</wicri:regionArea><wicri:noRegion>London NW3 2PF</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, Queen Square, University College London, London WC1N 3BG</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 5543, Universite Victor SegalenBordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux cedex</wicri:regionArea><wicri:noRegion>33076 Bordeaux cedex</wicri:noRegion><wicri:noRegion>33076 Bordeaux cedex</wicri:noRegion></affiliation></author><author><name sortKey="Brotchie, Jonathan" sort="Brotchie, Jonathan" uniqKey="Brotchie J" first="Jonathan" last="Brotchie">Jonathan Brotchie</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst, MC 11-419, Toronto, Ontario M5T 2S8</wicri:regionArea><wicri:noRegion>Ontario M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Calon, Frdric" sort="Calon, Frdric" uniqKey="Calon F" first="Frdric" last="Calon">Frdric Calon</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Molecular Endocrinology and Oncology Research Centre, Centre Hospitalier de l'Universit Laval Research Centre (CHUL), Quebec (QC), Canada, G1V 4G2 and Faculty of Pharmacy, Laval University, Quebec G1K 7P4</wicri:regionArea><wicri:noRegion>Quebec G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Collingridge, Graham L" sort="Collingridge, Graham L" uniqKey="Collingridge G" first="Graham L." last="Collingridge">Graham L. 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These symptoms can be treated successfully with a range of drugs that include levodopa, inhibitors of the enzymatic breakdown of levodopa and dopamine agonists delivered by oral, subcutaneous, transcutaneous, intravenous or intra-duodenal routes. However, Parkinson's disease involves degeneration of non-dopaminergic neurons and the treatment of the resulting predominantly non-motor features remains a challenge. This review describes the important recent advances that underlie the development of novel dopaminergic and non-dopaminergic drugs for Parkinson's disease, and also for the motor complications that arise from the use of existing therapies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Espagne</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name></noRegion><name sortKey="Collingridge, Graham L" sort="Collingridge, Graham L" uniqKey="Collingridge G" first="Graham L." last="Collingridge">Graham L. Collingridge</name><name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name><name sortKey="Novre, Nicolas Le" sort="Novre, Nicolas Le" uniqKey="Novre N" first="Nicolas Le" last="Novre">Nicolas Le Novre</name><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name></country><country name="France"><noRegion><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name></noRegion><name sortKey="Hirsch, Etienne" sort="Hirsch, Etienne" uniqKey="Hirsch E" first="Etienne" last="Hirsch">Etienne Hirsch</name><name sortKey="Hirsch, Etienne" sort="Hirsch, Etienne" uniqKey="Hirsch E" first="Etienne" last="Hirsch">Etienne Hirsch</name><name sortKey="Spampinato, Umberto" sort="Spampinato, Umberto" uniqKey="Spampinato U" first="Umberto" last="Spampinato">Umberto Spampinato</name></country><country name="Canada"><noRegion><name sortKey="Brotchie, Jonathan" sort="Brotchie, Jonathan" uniqKey="Brotchie J" first="Jonathan" last="Brotchie">Jonathan Brotchie</name></noRegion><name sortKey="Calon, Frdric" sort="Calon, Frdric" uniqKey="Calon F" first="Frdric" last="Calon">Frdric Calon</name></country><country name="Allemagne"><noRegion><name sortKey="Ferger, Borris" sort="Ferger, Borris" uniqKey="Ferger B" first="Borris" last="Ferger">Borris Ferger</name></noRegion><name sortKey="Hengerer, Bastian" sort="Hengerer, Bastian" uniqKey="Hengerer B" first="Bastian" last="Hengerer">Bastian Hengerer</name></country><country name="Espagne"><noRegion><name sortKey="Obeso, Jos A" sort="Obeso, Jos A" uniqKey="Obeso J" first="Jos A." last="Obeso">Jos A. Obeso</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name></noRegion><name sortKey="Davidai, Giora" sort="Davidai, Giora" uniqKey="Davidai G" first="Giora" last="Davidai">Giora Davidai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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